Analysis of Hypericin-Mediated Effects and Implications for Targeted Photodynamic Therapy
نویسندگان
چکیده
منابع مشابه
Analysis of Hypericin-Mediated Effects and Implications for Targeted Photodynamic Therapy
The phototoxic effect of hypericin can be utilized for Photodynamic Therapy (PDT) of cancer. After intravenous application and systemic distribution of the drug in the patient's body, the tumor site is exposed to light. Subsequently, toxic reactive oxygen species (ROS) are generated, inducing tumor cell death. To prevent unwanted activation of the drug in other regions of the body, patients hav...
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Ovarian cancer is the fourth most frequent cause of cancer-related death in women in the United States. The currently recommended treatment is a combination of surgery followed by chemotherapy. However, ovarian cancer is characterized by the development of peritoneal micrometastases. These latter, hardly detectable by conventional method, are therefore suboptimally treated by standard surgery. ...
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Hypericin (Hyp) is traditionally used as an antidepressant and antiviral agent. It selectively accumulates in spheroids and is also used as a photosensitizer in the photodynamic therapy of cancer. The present study aimed to investigate the cytotoxic effect of Hyp‑mediated photodynamic therapy (Hyp‑PDT) on cell growth and apoptosis of K562 leukemia cells, and to examine the underlying mechanisms...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2017
ISSN: 1422-0067
DOI: 10.3390/ijms18071388